منابع مشابه
Gene amplification in carcinogenesis
Gene amplification increases the number of genes in a genome and can give rise to karyotype abnormalities called double minutes (DM) and homogeneously staining regions (HSR), both of which have been widely observed in human tumors but are also known to play a major role during embryonic development due to the fact that they are responsible for the programmed increase of gene expression. The eti...
متن کاملCytogenetic evidence for gene amplification in mouse skin carcinogenesis.
Using our recently developed methodology for cytogenetic evaluation of solid tumors, we analyzed the occurrence of double minutes (DM) in chemically induced mouse skin carcinomas and papillomas. These studies revealed that DM were observed in 10% of the squamous cell carcinomas and in none of the papillomas screened. In addition, we analyzed four cell lines derived from mouse skin papillomas an...
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INTRODUCTION ..................................................................................... 417 A Leishmania Primer ............................................................................ 418 The Leishmania Genome and Circular DNAs ............................................... 419 MULTIPLE MECHANISMS OF DRUG RESISTANCE ...................................... 420 GENES AMPLIFIED IN ...
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Although a combination of genomic and epigenetic alterations are implicated in the multistep transformation of normal squamous esophageal epithelium to Barrett esophagus, dysplasia, and adenocarcinoma, the combinatorial effect of these changes is unknown. By integrating genome-wide DNA methylation, copy number, and transcriptomic datasets obtained from endoscopic biopsies of neoplastic progress...
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The human homologue of the murine double minute 2 gene (MDM2), a p53-binding protein which may act as a regulator of p53 protein function, has recently heen cloned. Initial studies of this gene in a variety of human tumors have shown frequent gene amplification in most types of sarcomas, including osteosarcomas. Amplification of the MIÃŒM2 gene may produce a functional inactivation of the p53 p...
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ژورنال
عنوان ژورنال: Genetics and Molecular Biology
سال: 2006
ISSN: 1415-4757
DOI: 10.1590/s1415-47572006000100001